Aconitum Napellus / True Monkshood Seeds / Wolf's Ban

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Though various species of aconite have been considered important medicinal plants by most traditions in areas where it grows, it has become a feared agent to avoid in much of the West. This is unfortunate, because in appropriate doses aconite is generally very safe and has many beneficial actions. Thorough knowledge of the herb is essential to insure safety, but given this, it serves as a potent addition to the botanical armamentarium.

INDICATIONS

Aconite has been used as a pain remedy wherever it is found. Headaches, rheumatic pains, arthritis, inflammatory pain, sciatica, pruritus ani, neuralgias and colicky pains have been treated historically with this plant (Sharp, 1933; Felter, 1922). It is active when taken internally and when applied externally. Modern clinical trials are lacking.

Aconite has also been used to reduce extreme fevers (Felter, 1922). This antipyretic action has been confirmed in animal studies, but its exact mechanism remains unknown (Hikino et al., 1979). Interestingly, processed lateral roots of Sichuan aconite are also considered critical in traditional Chinese medicine for helping patients with extreme weakness and cold subsequent to severe diarrhea or vomiting (Benksy et al., 1993).

ALLAPININE AND ARRHYTHMIAS

Aconite also affects cardiac function. Overdose, as discussed later, can readily cause arrhythmias, while lower doses can actually correct them. The Institute of the Chemistry of Plant Sciences in Uzbekistan has developed a product dubbed allapinine from the local species Aconitum leucostomum and A. septentrionale, and has shown in multiple clinical trials that it can correct supraventricular and ventricular extrasystoles, atrial fibrillation, Wolff-Parkinson-White syndrome and paroxysmal ventricular tachycardia (Kadyrova et al., 1990; Smetnev et al., 1988). It has been shown effective compared to placebo and several standard anti-arrhythmic drugs. It is not clear whether this product is available in North America.

PREPARATIONS AND DOSES

Aconite preparations made from fresh, raw materials must be handled with extreme care. They are very potent, and only very small doses are necessary for strong action. The therapeutic window is also small with these extracts. A typical adult dose of a full-strength (1:2-1:3 weight:volume) tincture of fresh above-ground parts of Aconitum columbianum is 2-3gtt every 2-3 hours for acute pain or fever. For tinctures made from cooked, dried lateral roots of any aconite, the dose is 3-5gtt every 2-3 hours. Topically, tincture should be mixed with a cream base and applied very conservatively to the skin overlying the affected area. Thus, on average, only 5-10gtt of tincture for every limb or the face should be applied in the cream base. Aconite alkaloids are readily absorbed transcutaneously and can cause systemic toxicity.

MECHANISMS OF ACTION

Aconites are members of the Ranunculaceae family, which is known for its diversity and its alkaloids. Aconitine and mesaconitine are two alkaloids found in fresh roots of various species of Aconitum (up to 0.6% of the total weight of the root are alkaloids). These alkaloids and their metabolites act on voltage-sensitive sodium channels in excitable tissues (Friese et al., 1997). Fresh roots with their intact alkaloids are significantly more potent and have higher potential for toxicity than dried or cooked roots. Heat converts aconitine and mesaconitine to benzylaconine derivatives, which are significantly less potent and safer.

Studies in mice have shown that aconite extracts and isolated extracts are potent inflammation modulators, equal in potency to or more so than corticosteroids in blocking angiogenesis in experimental arthritis (Luo et al., 1991).

TOXICOLOGY

Aconite is potentially lethal in all forms, though dried and cooked forms are less so. The major problem encountered in overdose is arrhythmias. Doses of 2g of improperly processed root of Sichuan aconite and 10ml tincture have been shown to cause severe but non-lethal arrhythmias in some cases (Kolev et al., 1996; Lin et al., 2004). No long-term effects have been seen in survivors of aconite overdose (Tai et al., 1992). Atropine and systemic lidocaine have been used for overdose in China; other anti-arrhythmic drugs may also help. Charcoal hemoperfusion has also been reported as helpful treatment (Lin et al., 2002).

Aconite can also cause numbness and tingling, weakness, paralysis, anxiety, restlessness and blurred vision (Chan et al., 1994).

Aconite is contraindicated in pregnancy and lactation, and should be avoided for use in children unless absolutely necessary. It should be used with caution for patients with pre-existing arrhythmias.


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